"Agnosticism is epistemologically self-contradictory on its own assumptions because its claim to make no assertion about ultimate reality rests upon a most comprehensive assertion about ultimate reality."

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Agnosticism, in fact, is not a creed, but a method, the essence of which lies in the rigorous application of a single principle. ... Positively the principle may be expressed: In matters of the intellect, follow your reason as far as it will take you, without regard to any other consideration. And negatively: In matters of the intellect, do not pretend that conclusions are certain which are not demonstrated or demonstrable.

— Thomas Huxley