"You stayed around your children as long as you could, inhaling the ambient gold shavings of their childhood, and at the last minute you tried to see them off into life and hoped that the little piece of time you’d given them was enough to prevent them from one day feeling lonely and afraid and hopeless. You wouldn’t know the outcome for a long time."

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Lithium tweaks many mood-altering chemicals in the brain, and its effects are complicated. Most interesting, lithium seems to reset the body’s circadian rhythm, its inner clock. In normal people, ambient conditions, especially the sun, dictate their humors and determine when they are tuckered out for the day. They’re on a twenty-four-hour cycle. Bipolar people run on cycles independent of the sun. And run and run.

— Sam Kean