"The only thing that can effect a big change in personality is something that physically rewires the brain and/or alters the body's chemical milieu."

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You need a human story to intersect those points of interest with real stakes on the line, and then things start to be fun, where you can see the ramifications, you see the impact on people's lives of big changes - like taking a man of science, like a surgeon, and robbing him of his understanding of the universe and forcing him into a newer and wider understanding.

— Jon Spaihts