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When you read a book, the neurons in your brain fire overtime, deciding what the characters are wearing, how they're standing, and what it feels like the first time they kiss. No one shows you. The words make suggestions. Your brain paints the pictures.
Sep 29, 2025
Life and consciousness are the two great mysteries. Actually, their substrates are the inanimate. And how do you get from neurons shooting around in the brain to the thought that pops up in your head and mine? There's something deeply mysterious about that. And if you're not struck by the mystery, I think you haven't thought about it.
Octopuses have hundreds of suckers, each one equipped with its own ganglion with thousands of neurons. These 'mini-brains' are interconnected, making for a widely distributed nervous system. That is why a severed octopus arm may crawl on its own and even pick up food.
When the brain is working to remember something, similar patterns of neurons fire as they did during the perception of the original event. These networks are linked, and each time we revisit them, they become stronger and more associated. But they need the proper retrieval cues--words, smells, images-- for them to be brought back as memories
Space and time, not proteins and neurons, hold the answer to the problem of consciousness. When we consider the nerve impulses entering the brain, we realize that they are not woven together automatically, any more than the information is inside a computer.
We assume that we have free will and that we make decisions, but we don't. Neurons do. We decide that this sum total driving us is a decision we have made for ourselves. But it is not.
Maybe I don't have the most common kind of motor neuron disease, which usually kills in two or three years.
[N]o scientist likes to be criticized. ... But you don't reply to critics: "Wait a minute, wait a minute; this is a really good idea. I'm very fond of it. It's done you no harm. Please don't attack it." That's not the way it goes. The hard but just rule is that if the ideas don't work, you must throw them away. Don't waste any neurons on what doesn't work. Devote those neurons to new ideas that better explain the data. Valid criticism is doing you a favor.
A typical neuron makes about ten thousand connections to neighboring neurons. Given the billions of neurons, this means there are as many connections in a single cubic centimeter of brain tissue as there are stars in the Milky Way galaxy.
Given the billions of neurons, this means there are as many connections in a single cubic centimeter of brain tissue as there are stars in the Milky Way galaxy.
In our constant search for meaning in this baffling and temporary existence, trapped as we are within our three pounds of neurons, it is sometimes hard to tell what is real. We often invent what isn't there. Or ignore what is. We try to impose order, both in our minds and in our conceptions of external reality. We try to connect. We try to find truth. We dream and we hope. And underneath all of these strivings, we are haunted by the suspicion that what we see and understand of the world is only a tiny piece of the whole.
The number of neurons in the brain is very much larger than the number of components in a computer.
The human brain has 100 billion neurons, each neuron connected to 10 thousand other neurons. Sitting on your shoulders is the most complicated object in the known universe.
We are compelled to drive toward total knowledge, right down to the levels of the neuron and the gene. When we have progressed enough to explain ourselves in these mechanistic terms...the result might be hard to accept.
What do we mean by "knowledge" or "understanding"? And how do billions of neurons achieve them? These are complete mysteries. Admittedly, cognitive neuroscientists are still very vague about the exact meaning of words like "understand," "think," and indeed the word "meaning" itself.
The first attempts to consider the behavior of so-called "random neural nets" in a systematic way have led to a series of problems concerned with relations between the "structure" and the "function" of such nets. The "structure" of a random net is not a clearly defined topological manifold such as could be used to describe a circuit with explicitly given connections. In a random neural net, one does not speak of "this" neuron synapsing on "that" one, but rather in terms of tendencies and probabilities associated with points or regions in the net.
Whatever we call it - mind, character, soul - we like to think we possess something that is greater than the sum of our neurons and that animates us.
The cells and fibers of the brain must carry some kind of individual identification tags, presumably cytochemical in nature, by which they are distinguished one from another almost, in many regions, to the level of the single neurons.
If you start responding to every stimulus, then you end up as a nerve gas case, quite literally. Neurons fire at once.
It's this expandable capacity to represent reasons that we have that gives us a soul. But what's it made of? It's made of neurons. It's made of lots of tiny robots. And we can actually explain the structure and operation of that kind of soul, whereas an eternal, immortal, immaterial soul is just a metaphysical rug under which you sweep your embarrassment for not having any explanation.
Every thought, feeling, and emotion creates a molecule known as a neuropeptide. Neuropeptides travel throughout your body and hook onto receptor sites of cells and neurons. Your brain takes in the information, converts it into chemicals, and lets your whole body know if there's trouble in the world or cause for celebration. Your body is directly influenced as these molecules course through the bloodstream, delivering the energetic effect of whatever your brain is thinking and feeling.
There are billions of neurons in our brains, but what are neurons? Just cells. The brain has no knowledge until connections are made between neurons. All that we know, all that we are, comes from the way our neurons are connected.
The brain, or cerebrum, is a material entity located inside the skull which may be inspected, touched, weighed, and measured. It is composed of chemicals, enzymes, and humors which may be analyzed. Its structure is characterized by neurons, pathways, and synapses which may be examined directly when they are properly magnified.
Throughout our lifetimes we are constantly regenerating new brain cells in the hippocampus, a process called neurogenesis. New stem cells are constantly being born in the hippocampus that ultimately differentiate into fully functional neurons.
Imagine something a million times more powerful than your smartphone that is the size of a brain cell interfacing with your biological neurons. That will be the complete symbiosis. That will be when we augment our brains at the level of the neuron.
What the ordinary person means by a 'miracle' is some gross distortion or suspension of the laws of nature... but life itself strikes him as commonplace, when in truth a blade of grass or a neuron in the brain is a greater miracle.
The brain immediately confronts us with its great complexity. The human brain weighs only three to four pounds but contains about 100 billion neurons.
The structure of the human brain is enormously complex. It contains about 10 billion nerve cells (neurons), which are interlinked in a vast network through 1,000 billion junctions (synapses). The whole brain can be divided into subsections, or sub-networks, which communicate with each other in a network fashion. All this results in intricate patterns of intertwined webs, networks of nesting within larger networks.
Your brain is built of cells called neurons and glia - hundreds of billions of them. Each one of these cells is as complicated as a city.
There is a neuron in your brain that will respond only to pictures of Jennifer Aniston - provided you have had prior visual exposure to the actress. That neuron does not respond to pictures of Bill Clinton or Halle Berry. Only Jennifer. I used the story to explain the almost ridiculous plasticity of the organ. There is no such thing as Jennifer Aniston in our evolutionary history - she was born in 1969, for heaven's sake - but we are flexible enough to devote an entire cell to her if we have previously encountered her in some fashion.
The brain is a monstrous, beautiful mess. Its billions of nerve cells - called neurons - lie in a tangled web that displays cognitive powers far exceeding any of the silicon machines we have built to mimic it.
The brain is a monstrous, beautiful mess.
It might be thought the height of poor taste to ascribe good fortune to a healthy man with a young family struck down at the age of sixty by an incurable degenerative disorder from which he must shortly die. But there is more than one sort of luck. To fall prey to a motor neuron disease is surely to have offended the Gods at some point, and there is nothing more to be said. But if you must suffer thus, better to have a well-stocked head.
Since the idea that modification of synaptic function can provide a basis for memory arose shortly after the first anatomical description of the synapse a number of models (Hebb 1949 . . Hayek 1952 . . Kendel 1981) have been proposed in which various cognitive activities are represented by combinations of the firing patterns of individual neurons.
We are using the neurons, our identity, to constantly maintain our identity. Whether you are awake, asleep, or dreaming, this process is carried on. But, it is wearing you out.That is why I say the tragedy that is facing mankind is not AIDS or cancer, but Alzthiemer's disease.
Artificial intelligence is growing up fast, as are robots whose facial expressions can elicit empathy and make your mirror neurons quiver.
There is one brain organ that is optimised for understanding and articulating logical processes and that is the outer layer of the brain, called the cerebral cortex. Unlike the rest of the brain, this relatively recent evolutionary development is rather flat, only about 0.32 cm (0.12 in) thick and includes a mere 6 million neurons. This elaborately folded organ provides us with what little competence we do possess for understanding what we do and who we do it.
For me, consciousness is the most interesting unsolved problem of science, and, in fact, we may never know what it is about a particular arrangement of neurons that gives rise to consciousness. Our consciousness, like the air we breathe or like the passage of time, is central to our existence as intelligent beings.
Since the universe must contain millions of appropriate planets, consciousness in some form - but not with the paired eyes and limbs, and the brain built of neurons in the only example we know - may evolve frequently. But if only one origin of life in a million ever leads to consciousness, then Martian bacteria most emphatically do not imply Little Green Men.
Your brain has more than 100 billion cells, each connected to at least 20,000 other cells. The possible combinations are greater than the number of molecules in the known universe.
If my dramatic career doesn't work out, I will go on to research and find cures for Alzheimer's or Parkinson's and other motor neuron diseases. It's a very exciting field of research. But I'd like to continue in drama, so it wouldn't be very smart of me if I blew this amazing opportunity with an inappropriate lifestyle.
The doctor who diagnosed me with ALS, or motor neuron disease, told me that it would kill me in two or three years.
The ability to double our biomass - not by waiting several million years and growing to be the size of an elephant - but waiting a few hundred thousand years for neurons to sprout into our brains - ones capable of having us create emotional relationships with other members of our species. We thereby double our biomass not by getting bigger, but by creating an ally.
Here is a neuron that fires when I reach and grab something, but it also fires when I watch Joe reaching and grabbing something. ... It's as though this neuron is adopting the other person's point of view.
The brain immediately confronts us with its great complexity. The human brain weighs only three to four pounds but contains about 100 billion neurons. Although that extraordinary number is of the same order of magnitude as the number of stars in the Milky Way, it cannot account for the complexity of the brain. The liver probably contains 100 million cells, but 1,000 livers do not add up to a rich inner life.
The patterns of activity of neurons in sensory areas can be altered by patterns of attention. Experience coupled with attention leads to physical changes in the structure and future functioning of the nervous system. This leaves us with a clear physiological fact…moment by moment we choose and sculpt how our ever-changing minds will work. We choose who we will be in the next moment in a very real sense, and these choices are left embossed in physical form in our material selves.
When carbon (C), Oxygen (o) and hydrogen (H) atoms bond in a certain way to form sugar, the resulting compound has a sweet taste. The sweetness resides neither in the C, nor in the O, nor in the H; it resides in the pattern that emerges from their interaction. It is an emergent property. Moreover, strictly speaking, is not a property of the chemical bonds. It is a sensory experience that arises when the sugar molecules interact with the chemistry of our taste buds, which in turns causes a set of neurons to fire in a certain way. The experience of sweetness emerges from that neural activity.
Studies of decision-making in the monkey, where activity of single neurons in parietal cortex is recorded, you can see a lot about the time-accuracy trade-off in the monkey's decision, and you can see from the neuron's activity at what point in his accumulation of evidence he makes his decision to make a particular movement.
In its evolution from a more primitive nervous system, the brain, as an organ with ten or more billion neurons and many more connections between them must have changed and grown as a result of many accidents.
The most obvious – and easiest! – way to gain perspective is to put your work away for a while. The truth is, we don’t know how taking a break frees up the mind, but it does: Somehow it freshens our little neurons, or perhaps it prompts the brain to create more cleverness molecules. If you can bear to let a short piece sit a week and a book-length work a month, do so. Longer is fine, too; some authors have abandoned manuscripts for years before unearthing them and realizing, ‘Hey, this isn’t bad,’ and renewing their energy for the project.